手机说明书英文版:尼麦角林 英文版说明书问题

  Nicergoline is an ergoloid mesylate derivative used to treat senile dementia and other disorders with vascular origins手机说明书英文版。 It has been found to increase mental agility and enhance clarity and perception。

   It decreases vascular resistance and increases arterial blood flow in the brain, improving the utilization of oxygen and glucose by brain cells手机说明书英文版。

   It has similar vasoactive properties in other areas of the body, particularly the lungs手机说明书英文版。

It is used for vascular disorders such as cerebral thrombosis and atherosclerosis, arterial blockages in the limbs, Raynaud's disease, vascular migraines, and retinopathy手机说明书英文版。

Nicergoline has been registered in over fifty countries and has been used for more than three decades for the treatment of cognitive, affective, and behavioral disorders of older people手机说明书英文版。

  [1]

It is marketed under the trade name Sermion手机说明书英文版。

[edit] Pharmacological action

Nicergoline is an ergot alkaloid derivative that acts as a potent and selective alpha-1A adrenergic receptor antagonist [2] The IC(50) of nicergoline in vitro has been reported to be 0手机说明书英文版。

  2 nM [3] The primary action of nicergoline is to increase arterial blood flow by vasodilation手机说明书英文版。 Furthermore, it is known that Nicergoline inhibits platelet aggregation。

   Studies have shown that Nicergoline also increases nerve growth factor in the aged brain手机说明书英文版。

[edit] Use and dosage

Nicerogline is used in the following cases:

Acute and chronic cerebral metabolic-vascular disorders (cerebral arteriosclerosis, thrombosis and cerebral embolism, transitory cerebral ischaemia)手机说明书英文版。

   Acute and chronic peripheral metabolic-vascular disorders (organic and functional arteriopathies of the limbs), Raynaud’s disease and other syndromes caused by altered peripheral irrigation手机说明书英文版。

Migraines of vascular origin

Coadjutant therapy in clinical situations accompanied by platelet hyper-aggregability, arterial tension手机说明书英文版。

Corio-retinal vascular disorders: , diabetic retinopathy, macular degeneration and retinal angiosclerosis

Oto-vestibular problems of a vascular nature: dizziness, auditory hallucinations, hypoacusis手机说明书英文版。

Dosages for known conditions are usually administered at 5-10mg three times a day, however anti-aging preventative purposes may want to consider 5mg once or twice a day more adequate手机说明书英文版。

  [4]

[edit] Contraindications and cautions

Persons suffering from acute bleeding, myocardial infarction (heart conditions), hypertension, bradycardia or using alpha or beta receptor agonists should consult with their physician before use手机说明书英文版。

   Although toxicology studies have not shown nicergoline to have any teratogenic effect, the use of this medicine during pregnancy should be limited to those cases where it is absolutely necessary手机说明书英文版。

[edit] Side effects

Medicines and their possible side effects can affect individual people in different ways手机说明书英文版。

   The following are some of the side effects that are known to be associated with this medicine手机说明书英文版。 Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect。

   Nicergoline can cause side effects they are usually limited to nausea, hot flushes, mild gastric upset, hypotension and dizziness手机说明书英文版。

   At high dosages bradycardia, increased appetite, agitation, diarrhea and perspiration have been known to present themselves手机说明书英文版。

   There was a single case of Acute Interstitial Nephritis手机说明书英文版。[5]

[edit] Interactions

Nicergoline is known to enhance the cardiac depressive effects of propranolol (Inderal) - caution is advised手机说明书英文版。

   At high dosages, it is advisable to seek one’s physician's guidance if combining with potent vasodilators such as bromocriptine, ginko biloba, hydergine, picamilone, vinpocetine or xanthinol nicotinate手机说明书英文版。

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